In the field of micro technologies for the development of 3D models, the research activity focuses on the design, development and characterization of advanced 3D bioengineered in vitro models, i.e., bioactive tissue/organ constructs, containing one or more cell types and able to mimic healthy and pathological conditions. In parallel, the research is carried out considering the optimization of advanced biomatrices/bioinks based on specifically selected materials (e.g. gelatin, silk, waste materials), having chemical, biochemical and mechanical properties such as to reproduce the physiological microenvironment in vivo in the body district of interest. The development of these models is aimed at the creation of versatile platforms, primarily for applications in the context of personalized medicine.